Super-resolution with Binary Priors: Theory and Algorithms.

The problem of super-resolution is concerned with the reconstruction of temporally/spatially localized events (or spikes) from samples of their convolution with a low-pass filter. Distinct from prior works which exploit sparsity in appropriate domains in order to solve the resulting ill-posed problem, this paper explores the role of binary priors in super-resolution, where the spike (or source) amplitudes are assumed to be binary-valued. Our study is inspired by the problem of neural spike deconvolution, but also applies to other applications such as symbol detection in hybrid millimeter wave communication systems. This paper makes several theoretical and algorithmic contributions to enable binary super-resolution with very few measurements. Our results show that binary constraints offer much stronger identifiability guarantees than sparsity, allowing us to operate in "extreme compression" regimes, where the number of measurements can be significantly smaller than the sparsity level of the spikes. To ensure exact recovery in this "extreme compression" regime, it becomes necessary to design algorithms that exactly enforce binary constraints without relaxation. In order to overcome the ensuing computational challenges, we consider a first order auto-regressive filter (which appears in neural spike deconvolution), and exploit its special structure. This results in a novel formulation of the super-resolution binary spike recovery in terms of binary search in one dimension. We perform numerical experiments that validate our theory and also show the benefits of binary constraints in neural spike deconvolution from real calcium imaging datasets.

Enhanced detection of paramagnetic fluorine-19 magnetic resonance imaging agents using zero echo time sequence and compressed sensing.

Fluorine-19 (19 F) magnetic resonance imaging (MRI) is an emerging technique offering specific detection of labeled cells in vivo. Lengthy acquisition times and modest signal-to-noise ratio (SNR) makes three-dimensional spin-density-weighted 19 F imaging challenging. Recent advances in tracer paramagnetic metallo-perfluorocarbon (MPFC) nanoemulsion probes have shown multifold SNR improvements due to an accelerated 19 F T1 relaxation rate and a commensurate gain in imaging speed and averages. However, 19 F T2 -reduction and increased linewidth limit the amount of metal additive in MPFC probes, thus constraining the ultimate SNR. To overcome these barriers, we describe a compressed sampling (CS) scheme, implemented using a "zero" echo time (ZTE) sequence, with data reconstructed via a sparsity-promoting algorithm. Our CS-ZTE scheme acquires k-space data using an undersampled spherical radial pattern and signal averaging. Image reconstruction employs off-the-shelf sparse solvers to solve a joint total variation and l1 -norm regularized least square problem. To evaluate CS-ZTE, we performed simulations and acquired 19 F MRI data at 11.7 T in phantoms and mice receiving MPFC-labeled dendritic cells. For MPFC-labeled cells in vivo, we show SNR gains of ~6.3 × with 8-fold undersampling. We show that this enhancement is due to three mechanisms including undersampling and commensurate increase in signal averaging in a fixed scan time, denoising attributes from the CS algorithm, and paramagnetic reduction of T1 . Importantly, 19 F image intensity analyses yield accurate estimates of absolute quantification of 19 F spins. Overall, the CS-ZTE method using MPFC probes achieves ultrafast imaging, a substantial boost in detection sensitivity, accurate 19 F spin quantification, and minimal image artifacts.

Identifying brain network topology changes in task processes and psychiatric disorders.

A central goal in neuroscience is to understand how dynamic networks of neural activity produce effective representations of the world. Advances in the theory of graph measures raise the possibility of elucidating network topologies central to the construction of these representations. We leverage a result from the description of lollipop graphs to identify an iconic network topology in functional magnetic resonance imaging data and characterize changes to those networks during task performance and in populations diagnosed with psychiatric disorders. During task performance, we find that task-relevant subnetworks change topology, becoming more integrated by increasing connectivity throughout cortex. Analysis of resting state connectivity in clinical populations shows a similar pattern of subnetwork topology changes; resting scans becoming less default-like with more integrated sensory paths. The study of brain network topologies and their relationship to cognitive models of information processing raises new opportunities for understanding brain function and its disorders.

Sparse Bayesian learning for beamforming using sparse linear arrays.

Sparse linear arrays such as co-prime and nested arrays can resolve more sources than the number of sensors. In contrast, uniform linear arrays (ULA) cannot resolve more sources than the number of sensors. This paper demonstrates this using Sparse Bayesian learning (SBL) and co-array MUSIC for single frequency beamforming. For approximately the same number of sensors, co-prime and nested arrays are shown to outperform ULA in root mean squared error. This paper shows that multi-frequency SBL can significantly reduce spatial aliasing. The effects of different sparse sub-arrays on SBL performance are compared qualitatively using the Noise Correlation 2009 experimental data set.